Understanding the chemistry behind the antioxidant activities of butylated hydroxytoluene (BHT): A review

Yehye, Wageeh Abdulhadi and Abd Rahman, Noorsaadah and Ariffin, Azhar and Hamid, Sharifah Bee Abd and Alhadi, A.A. and Kadir, F.A. and Yaeghoobi, M. (2015) Understanding the chemistry behind the antioxidant activities of butylated hydroxytoluene (BHT): A review. European Journal of Medicinal Chemistry, 101. pp. 295-312. ISSN 0223-5234, DOI https://doi.org/10.1016/j.ejmech.2015.06.026.

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Official URL: http://dx.doi.org/10.1016/j.ejmech.2015.06.026


Hindered phenols find a wide variety of applications across many different industry sectors. Butylated hydroxytoluene (BHT) is a most commonly used antioxidant recognized as safe for use in foods containing fats, pharmaceuticals, petroleum products, rubber and oil industries. In the past two decades, there has been growing interest in finding novel antioxidants to meet the requirements of these industries. To accelerate the antioxidant discovery process, researchers have designed and synthesized a series of BHT derivatives targeting to improve its antioxidant properties to be having a wide range of antioxidant activities markedly enhanced radical scavenging ability and other physical properties. Accordingly, some structure–activity relationships and rational design strategies for antioxidants based on BHT structure have been suggested and applied in practice. We have identified 14 very sensitive parameters, which may play a major role on the antioxidant performance of BHT. In this review, we attempt to summarize the current knowledge on this topic, which is of significance in selecting and designing novel antioxidants using a well-known antioxidant BHT as a building-block molecule. Our strategy involved investigation on understanding the chemistry behind the antioxidant activities of BHT, whether through hydrogen or electron transfer mechanism to enable promising anti-oxidant candidates to be synthesized.

Item Type: Article
Funders: Ministry of Higher Education (MOHE) and University of Malaya: grants (FP050-2014B, RP017C-13AET and GC001C-14AET)
Uncontrolled Keywords: Antioxidant; Butylated hydroxytoluene; Free radical; Reactive oxygen species; Phenol
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Nanotechnology & Catalysis Research Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 21 Sep 2018 06:27
Last Modified: 27 Aug 2019 06:20
URI: http://eprints.um.edu.my/id/eprint/19378

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