Curcuma mangga-Mediated Synthesis of Gold Nanoparticles: Characterization, Stability, Cytotoxicity, and Blood Compatibility

Foo, Y.Y. and Periasamy, V. and Kiew, L.V. and Kumar, G.G. and Malek, S.N.A. (2017) Curcuma mangga-Mediated Synthesis of Gold Nanoparticles: Characterization, Stability, Cytotoxicity, and Blood Compatibility. Nanomaterials, 7 (6). p. 123. ISSN 2079-4991, DOI

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The utilization of toxic chemicals as reducing and stabilizing agents in the preparation of gold nanoparticles (AuNPs) has increased in vivo toxicity and thus limited its application in clinical settings. Herein, we propose an alternative method of preparing highly stable AuNPs, where non-toxic Curcuma mangga (CM) extract was used as a single reducing and stabilizing agent to overcome the aforementioned constraints. The morphological images enunciated that the homogeneously dispersed AuNPs exhibited spherical morphology with an average particle diameter of 15.6 nm. Fourier Transform infrared (FTIR) and cyclic voltammetry analysis demonstrated that carbonyl groups of terpenoids in CM extract played an important role in the formation and stabilization of AuNPs. Green-synthesized AuNPs were found to have good stability in physiological media after 24 h of dispersion. The AuNPs were also cytocompatible with human colon fibroblast cell (CCD-18Co) and human lung fibroblast cell (MRC-5). Hemocompatibility tests revealed that the AuNPs were blood-compatible, with less than 10% of hemolysis without any aggregation of erythrocytes. The current study suggests potential in employing a CM-extract-based method in the preparation of AuNPs for anticancer diagnosis and therapy.

Item Type: Article
Funders: Ministry of Education Malaysia: High Impact Research (HIR) MoE Grant UM.C/625/1/HIR/MoE/SC/02, University Malaya Research Grant (UMRG) RG321-15AFR and PPP grant, PG199-2014B
Uncontrolled Keywords: Gold nanoparticles; Green synthesis; In vitro stability; Biocompatible; Phytochemicals; Hemocompatibility
Subjects: Q Science > Q Science (General)
Q Science > QC Physics
Q Science > QH Natural history
R Medicine
Divisions: Faculty of Medicine
Faculty of Science > Department of Physics
Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 12 Sep 2018 01:26
Last Modified: 12 Sep 2018 01:26

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