Lectins: an effective tool for screening of potential cancer biomarkers

Hashim, Onn Haji and Jayapalan, J.J. and Lee, Cheng Siang (2017) Lectins: an effective tool for screening of potential cancer biomarkers. PeerJ, 5. e3784. ISSN 2167-8359, DOI https://doi.org/10.7717/peerj.3784.

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Official URL: http://dx.doi.org/10.7717/peerj.3784


In recent years, the use of lectins for screening of potential biomarkers has gained increased importance in cancer research, given the development in glycobiology that highlights altered structural changes of glycans in cancer associated processes. Lectins, having the properties of recognizing specific carbohydrate moieties of glycoconjugates, have become an effective tool for detection of new cancer biomarkers in complex bodily fluids and tissues. The specificity of lectins provides an added advantage of selecting peptides that are differently glycosylated and aberrantly expressed in cancer patients, many of which are not possibly detected using conventional methods because of their low abundance in bodily fluids. When coupled with mass spectrometry, research utilizing lectins, which are mainly from plants and fungi, has led to identification of numerous potential cancer biomarkers that may be used in the future. This article reviews lectin-based methods that are commonly adopted in cancer biomarker discovery research.

Item Type: Article
Uncontrolled Keywords: Biomarker; Cancer; Glycan; Glycosylation; Lectin; Proteomics
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 07 Sep 2018 01:37
Last Modified: 24 Oct 2019 07:57
URI: http://eprints.um.edu.my/id/eprint/19174

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