Mammographic compression in Asian women

Lau, S. and Aziz, Y.F.A. and Ng, K.H. (2017) Mammographic compression in Asian women. PLoS ONE, 12 (4). e0175781. ISSN 1932-6203, DOI

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Objectives: To investigate: (1) the variability of mammographic compression parameters amongst Asian women; and (2) the effects of reducing compression force on image quality and mean glandular dose (MGD) in Asian women based on phantom study. Methods: We retrospectively collected 15818 raw digital mammograms from 3772 Asian women aged 35-80 years who underwent screening or diagnostic mammography between Jan 2012 and Dec 2014 at our center. The mammograms were processed using a volumetric breast density (VBD) measurement software (Volpara) to assess compression force, compression pressure, compressed breast thickness (CBT), breast volume, VBD and MGD against breast contact area. The effects of reducing compression force on image quality and MGD were also evaluated based on measurement obtained from 105 Asian women, as well as using the RMI156 Mammographic Accreditation Phantom and polymethyl methacrylate (PMMA) slabs. Results: Compression force, compression pressure, CBT, breast volume, VBD and MGD correlated significantly with breast contact area (p<0.0001). Compression parameters including compression force, compression pressure, CBT and breast contact area were widely variable between [relative standard deviation (RSD)≥21.0%] and within (p<0.0001) Asian women. The median compression force should be about 8.1 daN compared to the current 12.0 daN. Decreasing compression force from 12.0 daN to 9.0 daN increased CBT by 3.3-1.4 mm, MGD by 6.2-11.0%, and caused no significant effects on image quality (p>0.05). Conclusions: Force-standardized protocol led to widely variable compression parameters in Asian women. Based on phantom study, it is feasible to reduce compression force up to 32.5% with minimal effects on image quality and MGD.

Item Type: Article
Funders: Ministry of Education, Malaysia: High Impact Research Grant UM.C/HlR/MOHE/06, University of Malaya, Malaysia: Postgraduate Research Grant PG035-2013A
Uncontrolled Keywords: Adult; Aged; Aged, 80 and over; Asia; Asian Continental Ancestry Group; Breast; Breast Density; Female; Humans; Mammography; Middle Aged; Phantoms, Imaging; Retrospective Studies; Software
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 05 Sep 2018 08:50
Last Modified: 05 Sep 2018 08:50

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