Antibacterial properties of poly (octanediol citrate)/gallium-containing bioglass composite scaffolds

Zeimaran, E. and Pourshahrestani, S. and Djordjevic, I. and Pingguan-Murphy, Belinda and Kadri, Nahrizul Adib and Wren, A.W. and Towler, M.R. (2016) Antibacterial properties of poly (octanediol citrate)/gallium-containing bioglass composite scaffolds. Journal of Materials Science: Materials in Medicine, 27 (1). pp. 1-11. ISSN 0957-4530, DOI

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Bioactive glasses may function as antimicrobial delivery systems through the incorporation and subsequent release of therapeutic ions. The aim of this study was to evaluate the antimicrobial properties of a series of composite scaffolds composed of poly(octanediol citrate) with increased loads of a bioactive glass that releases zinc (Zn2+) and gallium (Ga3+) ions in a controlled manner. The antibacterial activity of these scaffolds was investigated against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The ability of the scaffolds to release ions and the subsequent ingress of these ions into hard tissue was evaluated using a bovine bone model. Scaffolds containing bioactive glass exhibited antibacterial activity and this increased in vitro with higher bioactive glass loads; viable cells decreased to about 20 % for the composite scaffold containing 30 % bioactive glass. The Ga3+ release rate increased as a function of time and Zn2+ was shown to incorporate into the surrounding bone.

Item Type: Article
Funders: Ministry of Higher Education Malaysia: High Impact Research Grant (UM.C/625/1/HIR/MOHE/ENG/58), University of Malaya Research Grant (UMRG, RG156-12AET)
Uncontrolled Keywords: Antibacterial Activity; Simulated Body Fluid; Bioactive Glass; Ga2O3; Composite Scaffold
Subjects: R Medicine
T Technology > TJ Mechanical engineering and machinery
Divisions: Faculty of Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 15 May 2018 06:15
Last Modified: 10 Feb 2020 08:40

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