Antimicrobial activity of a quaternized BODIPY against Staphylococcus strains

Aydin Tekdaş, D. and Viswanathan, G. and Zehra Topal, S. and Looi, C.Y. and Wong, W.F. and Min, G.Y.T. and Zorlu, Y. and Gürek, A.G. and Lee, H.B. and Dumoulin, F. (2016) Antimicrobial activity of a quaternized BODIPY against Staphylococcus strains. Organic and Biomolecular Chemistry, 14 (9). pp. 2665-2670. ISSN 1477-0520, DOI

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A novel BODIPY derivative was designed for biomedical applications. Its mono-quaternized structure ensured its water-solubility and suitable amphiphilicity. Showing no singlet oxygen generation to avoid damage to healthy cells, this new derivative proved to be an extremely promising antimicrobial agent, with activity equal or superior to ampicillin against MRS Staphylococcus strains with no short-term resistance issue. Its activity against MSS Staphylococcus strains was largely superior to those of ampicillin and reached the activity of vancomycin against MSS S. epidermidis. This latter result is in particular extremely promising for the treatment of hospital-acquired infections. Also the fluorescence properties of BODIPY allowed imaging of the uptake.

Item Type: Article
Uncontrolled Keywords: Antimicrobial agents; Medical applications; Microorganisms; Satellites
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 30 Nov 2017 06:27
Last Modified: 30 Nov 2017 06:27

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