Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs.

Hilmi, I. and Goh, K.L. (2006) Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs. Chinese Journal of Digestive Diseases, 7 (1). pp. 1-6. ISSN 1443-9611,

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Colorectal carcinoma is one of the commonest solid organ tumors in the world and its prevalence appears to be increasing in Asia. Recently, there has been much interest in various chemotherapeutic agents for the management of this condition, in particular nonsteroidal anti-inflammatory drugs (NSAIDs). There is a large amount of data that suggest traditional NSAIDs, as well as the new cyclooxygenase (COX)-2 selective inhibitors such as rofecoxib and celecoxib, have a role in the setting of primary and secondary prevention, and adjuvant therapy of both sporadic colorectal carcinoma and familial adenomatous polyposis. This review examines some of this data, as well as the potential problems and limitations of using these agents, particularly in light of the recent withdrawal of rofecoxib.

Item Type: Article
Additional Information: Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Uncontrolled Keywords: Chemoprevention; Clinical Trials as Topic; Colorectal Neoplasms/drug therapy
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 15 Jun 2011 01:48
Last Modified: 21 Oct 2014 04:48

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