The many faces of chlamydiae

Ngeow, Y. (2000) The many faces of chlamydiae. The Malaysian Journal of Pathology, 22 (2). pp. 55-64. ISSN 0126-8635, DOI 16329536.

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The application of modern research tools has broadened our understanding of the chlamydiae and their role in disease. Chlamydial genome analysis showed the presence of genes for ATP and peptidoglycan synthesis, contradicting the common belief that chlamydiae lack the ability to produce these compounds. Phylogenetic tree analysis suggests that chlamydiae could have evolved from an intracellular existence in amoebae. Newly discovered obligate intracellular organisms with chlamydia-like life-cycles have been classified as chlamydiae by rRNA homology with existing chlamydial species. A proposed new classification adds three new families to the order Chlamydiales as well as creates two genera and nine species within the family Chlamydiaceae. Chlamydiae are incriminated in an increasingly large spectrum of diseases both in humans and in animals. The emergence of multi-drug resistant C. trachomatis strains forewarns therapeutic problems with this organism. While C. pneumoniae remains a significant respiratory pathogen, the role it plays in the pathogenesis of atherosclerosis and ischaemic heart disease awaits definition.

Item Type: Article
Additional Information: Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia
Uncontrolled Keywords: Chlamydia/classification; Chlamydia/genetics; Chlamydia/pathogenicity
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 15 Jun 2011 01:41
Last Modified: 26 Oct 2018 01:52

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