An introduction to dengue-disease diagnostics

Darwish, Nadiya Taha and Alias, Y. and Khor, S.M. (2015) An introduction to dengue-disease diagnostics. Trends in Analytical Chemistry, 67. pp. 45-55. ISSN 0165-9936, DOI

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In this review, we discuss how dengue disease can be diagnosed accurately at the viremia phase and the fever phase. Diagnostic tools currently used to detect dengue virus (DENV) are virus isolation, capture IgM and IgG ELISA, real-time polymerase chain reaction (RT-PCR), and immunochromatography of the dengue NS1 antigen. First, we explain the advantages, the challenges and the limitations of different diagnostic tests. This account is followed by several examples using biosensors for detection of several important DENV biomarkers. Finally, we discuss our opinions regarding future perspectives in this field.

Item Type: Article
Uncontrolled Keywords: Biomarker; Biosensor; Capture IgM; Dengue NS1 antigen; Dengue virus; Diagnosis; IgG ELISA; Immunochromatography; Real-time polymerase chain reaction; Virus isolation
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Dr Sook Mei Khor
Date Deposited: 12 Jan 2016 02:17
Last Modified: 26 Oct 2018 06:49

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