Blood brain barrier and infection

Chaudhuri, J.D. (2000) Blood brain barrier and infection. Medical Science Monitor, 6 (6). pp. 1213-22. ISSN 1234-1010, DOI 11208482.

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The blood brain barrier (BBB) is a highly dynamic structure and consists of endothelial cells, which are characterized by the presence of tight junctions and relative lack of endocytic vesicles. The tight junctions are reinforced by the foot processes of the astrocytes. The BBB functions through these specialised structures, to maintain the environment of the brain in a steady state by regulating the influx and efflux of substances. The protective effect of the BBB is however, lost during bacterial and viral infections. The primary mechanism operative are an increase in the permeability of the BBB and/or direct invasion of the brain by microorganisms. Since the BBB is relatively impermeable to chemotherapeutic agents the treatment of CNS infections is difficult. This paper aims to examine the various mechanisms by which infection spreads to the brain, and suggest measures for successful drug delivery into the brain during infections.

Item Type: Article
Additional Information: Department of Anatomy, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia.
Uncontrolled Keywords: Biological Transport, Active; Blood-Brain Barrier/physiology; Central Nervous System Infections/drug therapy
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 10 Jun 2011 02:38
Last Modified: 26 Oct 2018 03:34

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