Positive outcomes of oil palm phenolics on degenerative diseases in animal models

Sambanthamurthi, Ravigadevi and Tan, Yew Ai and Sundram, Kalyana and Hayes, Kenneth C. and Abeywardena, Mahinda and Leow, Soon Sen and Sekaran, Shamala Devi and Sambandan, T.G. and Rha, Cho Kyun and Sinskey, Anthony J. and Subramaniam, Krishnan and Fairus, Syed and Wahid, Mohd Basri (2011) Positive outcomes of oil palm phenolics on degenerative diseases in animal models. British Journal of Nutrition, 106 (11). pp. 1664-1675. ISSN 0007-1145, DOI https://doi.org/10.1017/S0007114511002133.

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Official URL: https://doi.org/10.1017/S0007114511002133


It is well established that plant phenolics elicit various biological activities, with positive effects on health. Palm oil production results in large volumes of aqueous by-products containing phenolics. In the present study, we describe the effects of oil palm phenolics (OPP) on several degenerative conditions using various animal models. OPP reduced blood pressure in a NO-deficient rat model, protected against ischaemia-induced cardiac arrhythmia in rats and reduced plaque formation in rabbits fed an atherogenic diet. In Nile rats, a spontaneous model of the metabolic syndrome and type 2 diabetes, OPP protected against multiple aspects of the syndrome and diabetes progression. In tumour-inoculated mice, OPP protected against cancer progression. Microarray studies on the tumours showed differential transcriptome profiles that suggest anti-tumour molecular mechanisms involved in OPP action. Thus, initial studies suggest that OPP may have potential against several chronic disease outcomes in mammals.

Item Type: Article
Uncontrolled Keywords: Oil palm phenolics; CVD; Metabolic syndrome; Anti-tumour mechanisms
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Medicine
Depositing User: Dr Mohd Faizal Hamzah
Date Deposited: 07 Nov 2015 02:30
Last Modified: 24 Mar 2021 05:00
URI: http://eprints.um.edu.my/id/eprint/14637

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