Changing prognosis of childhood cancer--an overview.

Lin, H.P. (1993) Changing prognosis of childhood cancer--an overview. Annals of the Academy of Medicine, Singapore, 22 (2). pp. 182-6. ISSN 0304-4602, DOI 8363329.

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Significant advances in diagnosis and management have cured the majority of children with cancer. In the leukaemias, the commonest childhood malignancy, intensive induction-consolidation is important to ensure a lasting cure in about 65-80% and to eliminate the traditionally bad prognostic risk factors associated with less intensive treatment. Bone marrow transplantation (BMT) has a curative role in the minority who relapse particularly while on treatment. With few exceptions, most paediatric solid tumours are curable. Although the multimodal approach is responsible for the progress made, chemotherapy has emerged to play a dominant role. It has, in several tumours, obviated or reduced the need for radiotherapy and/or surgery. In Wilms' tumour and Hodgkin's disease, refinement of treatment is now in progress to reduce therapy-related morbidity while not sacrificing efficacy.

Item Type: Article
Additional Information: Department of Paediatrics, University of Malaya, Kuala Lumpur
Uncontrolled Keywords: Child, Preschool; Combined Modality Therapy
Subjects: R Medicine > RJ Pediatrics
Depositing User: Mr. Faizal Hamzah
Date Deposited: 01 Jun 2011 03:08
Last Modified: 21 Oct 2014 01:10

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