Myelodysplastic syndrome: a review from University Hospital, Kuala Lumpur

Ng, S.C. and Kuperan, P. and Bosco, J. and Menaka, N. (1990) Myelodysplastic syndrome: a review from University Hospital, Kuala Lumpur. Singapore Medical Journal, 31 (2). pp. 153-8. ISSN 0037-5675, DOI 2196685.

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Twenty patients with Myelodysplastic Syndrome (MDS) were diagnosed in University Hospital, Kuala Lumpur over a 5 year period. They were subclassified using the French American British (FAB) criteria. 90% of the patients were above 40 years old and the sex ratio was about equal. The predominant presenting symptom was anaemia and there was paucity of physical signs at presentation. Patients with 'aggressive' subtypes of MDS i.e. refractory anaemia with excess blasts (RAEB), refractory anaemia with excess blasts in transformation (RAEB(-)+) and chronic myelomonocytic leukaemia (CMML) had more frequent thrombocytopenia and neutropenia and their marrow pictures frequently had dysmegakaryopoiesis and dysgranulopoiesis as compared to more the "benign" subtypes i.e. refractory anaemia (RA) and refractory leukaemic anaemia with ringed sideroblasts (RARS). Four patients had leukaemic transformation and all of them came from the 'aggressive' subtypes. The current views on treatment of MDS are discussed.

Item Type: Article
Additional Information: Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur
Uncontrolled Keywords: Anemia, Sideroblastic/diagnosis
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 31 May 2011 07:39
Last Modified: 14 Jan 2019 01:26

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