Epidemiology of Helicobacter pylori infection in Malaysia--observations in a multiracial Asian population

Goh, Khean Lee (2009) Epidemiology of Helicobacter pylori infection in Malaysia--observations in a multiracial Asian population. Medical Journal of Malaysia, 64 (3). pp. 187-192. ISSN 0300-5283, DOI 20527265.

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Official URL: http://www.e-mjm.org/2009/v64n3/Helicobacter_pylor...


Observations of racial differences in the prevalence of Helicobacter pylori in Malaysia have been intriguing. The Indians and Chinese consistently have a higher prevalence compared to the Malays. The racial cohort theory has been proposed to explain these differences where transmission and perpetuation of infection takes place within a racial group rather than between races, races being separate owing to the low rate of interracial marriages. Studies have demonstrated distinctive bacterial strains between races. Phylogenetic studies have shown that H. pylori isolates amongst Chinese and Indians are distinctive while Malays have Indian and other strains suggesting a more recent acquisition of the bacterium from Indians. H. pylori is recognized as the major causative factor in peptic ulcer disease and gastric cancer. Despite the high prevalence of H. pylori, Indians have a relatively low prevalence of peptic ulcer disease and a low incidence of gastric cancer. This paradox with regards to gastric cancer has been termed the "Indian enigma". Bacterial strain differences between races may be putative but this observation may also indicate gastroprotective environmental factors or a lower genetic susceptibility to develop cancer in the Indians.

Item Type: Article
Additional Information: Head of Gastroenterology and Hepatology, Department of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. gohkl@um.edu.my
Uncontrolled Keywords: Helicobacter Infections/transmission
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 25 May 2011 03:38
Last Modified: 01 Mar 2019 06:01
URI: http://eprints.um.edu.my/id/eprint/1347

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