Interplay of transcription factors in T-cell differentiation and function: the role of Runx

Wong, W.F. and Kohu, K. and Chiba, T. and Sato, T. and Satake, M. (2011) Interplay of transcription factors in T-cell differentiation and function: the role of Runx. Immunology, 132 (2). pp. 157-164. ISSN 0019-2805, DOI

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Over the past years, increasing numbers of distinct subsets have been discovered and identified for a T lymphocytes’ entity. Differentiation and function of each T cell subset are controlled by a specific master transcription factor. Importantly, Runt-related transcription factors, particularly Runx1 and Runx3, interplay with these master regulators in various aspects of T cells’ immunity. In this review article, we first explain roles of Th-Pok and Runx3 in differentiation of CD4 versus CD8 single positive cells, and later focus on cross-regulation of Th-Pok and Runx3 and their relationship with other factors such as TCR strength. Next, we provide evidences for the direct interplay of Runx1/3 with T-bet and GATA3 during Th1 versus Th2 commitment to activate or silence transcription of signature cytokine genes, IFNγ and IL4. Lastly, we explain feed-forward relationship between Runx1 and Foxp3 and discuss roles of Runx1 in regulatory T cells’ suppressive activity. This review highlights an essential importance of Runx molecules in controlling various T cell subsets’ differentiation and functions through molecular interplay with the master transcription factors in terms of protein-protein interaction as well as regulation of gene expression.

Item Type: Article
Uncontrolled Keywords: Cell differentiation; Gene expression; Gene targeting; T lymphocytes; Transcription factor
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 13 Mar 2015 01:41
Last Modified: 13 Mar 2015 01:41

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