Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma

Mohamed, G. and Vrzalikova, K. and Cader, F.Z. and Vockerodt, M. and Nagy, E. and Flodr, P. and Yap, L.F. and Diepstra, A. and Kluin, P.M. and Rosati, S. and Murray, P. (2014) Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma. Journal of General Virology. ISSN 0022-1317,

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/24893782


The relationship between Epstein-Barr virus (EBV) and the germinal centre (GC) of the asymptomatic host remains an enigma. The occasional appearance of EBV-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that EBV numbers in the GC are subject to immune control. The relationship, if any, between lymphoid hyperplasia with EBV-positive germinal centres and subsequent or concurrent lymphomagenesis remains to be clarified. As far as the development of EBV-associated Hodgkin's lymphoma is concerned, the suppression of virus replication, mediated by LMP1 on the one hand, and the loss of B-cell receptor signalling on the other, appears to be an important pathogenic mechanism. A further important emerging concept is that alterations in the microenvironment of the EBV-infected B-cell may be important for lymphomagenesis.

Item Type: Article
Additional Information: Doi: 10.1099/vir.0.066712-0
Uncontrolled Keywords: Activation; Center B-Cells, Reed-Strenberg, EBV-Infacted-Cells; Disease; Terminal Differentiation
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry
Depositing User: Mr Ahmad Azwan Azman
Date Deposited: 20 Nov 2014 02:04
Last Modified: 20 Nov 2014 02:04
URI: http://eprints.um.edu.my/id/eprint/11367

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