Effectiveness and safety of olanzapine in the treatment of Asian outpatients with schizophrenia

Habil, H. and Gondoyoewono, H. and Chaudhry, H.R. and Samanwongthai, U. and Hamid, A.R.A. and Hashmi, I.T. and Budiman, R. and Knowles, A.G. and Buenaventura, R. (2007) Effectiveness and safety of olanzapine in the treatment of Asian outpatients with schizophrenia. International Journal of Clinical Pharmacology and Therapeutics, 45 (12). pp. 631-642. ISSN 0946-1965,

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/18184531


Objective: The objective of this study was to assess the effectiveness and safety of olanzapine in the treatment of schizophrenia among Asian patients in an outpatient setting. Methods: This was an open-label, prospective, observational study involving 339 patients from Indonesia, Pakistan, Malaysia, Thailand, and Singapore. Brief Psychiatric Rating Scale (BPRS), Clinical Global Impression Severity scale (CGI-S), and safety parameters were assessed. Results: 62 of patients responded to olanzapine treatment, defined a priori as a reduction in BPRS of > 40 from baseline. Following the 8-week treatment period, the BPRS total, BPRS positive, BPRS negative, and CGI-S scores decreased by 18.7 (95 CT: 17.4 20.2), 6.1 (5.6, 6.6), 2.9 (2.6, 3.2), and 1.5 points (median 1.0), respectively (p < 0,0001). In total, 31 of the 339 patients (9.1) failed to complete the study according to the study description. Loss to follow-up and personal conflict were the most common reasons for discontinuation. There were 30 treatment-emergent adverse events with six serious cases, assessed as unrelated to study drug, reported. Conclusion: This study further demonstrates the effectiveness and safety of olanzapine in actual clinical practice settings, in reducing the severity of psychopathological symptoms in Asian patients with schizophrenia.

Item Type: Article
Uncontrolled Keywords: Olanzapine; schizophrenia; Asian patients; observational study; safety; atypical antipsychotic olanzapine; double-blind
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 17 Dec 2014 02:52
Last Modified: 17 Dec 2014 02:52
URI: http://eprints.um.edu.my/id/eprint/11047

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