Escitalopram in the treatment of Malaysian patients with Obsessive-compulsive disorder

Hatim, A. and Gill, J.S. and Jambunathan, S.T. and Yen, T.H. and Ariff, M. and Lemming, O.M. and Azhar, M.Z. (2008) Escitalopram in the treatment of Malaysian patients with Obsessive-compulsive disorder. Hong Kong J Psychiatry, 18. pp. 152-157. ISSN 1026-2121,

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Objective: This post-hoc analysis examined the efficacy and tolerability of escitalopram in the prevention of relapse in Malaysian patients with obsessive-compulsive disorder. Participants and Methods: In Malaysia, 47 patients with obsessive-compulsive disorder were treated with open-label escitalopram (10 mg or 20 mg/day) for 16 weeks, after which the 34 responders (Yale-Brown Obsessive Compulsive Scale total decrease score, 25) were randomised to placebo or escitalopram for 24 weeks, using a double-blind protocol. Results: The primary efficacy analysis suggested a trend in favour of escitalopram treatment with respect to time to relapse (log-rank test, p = 0.07). A higher proportion of patients relapsed after placebo treatment (5 of 14, 36) than with escitalopram treatment (2 of 20, 10) Fishers exact test, 2-sided; p = 0.10. The risk of relapse was 4-fold higher for placebo than escitalopram treatment (p = 0.09). During the double-blind period, the proportion of patients reporting treatment-emergent adverse events was comparable in the 2 groups (10% in the escitalopram group vs. 14% in the placebo group); no serious events being reported. Conclusions: This post-hoc subgroup analysis suggests that escitalopram is well tolerated in Malaysian patients with obsessive-compulsive disorder and appears to confer an advantage over placebo, in terms of time to relapse and other efficacy variables.

Item Type: Article
Uncontrolled Keywords: Citalopram; Obsessive-compulsive disorder; Recurrence; Treatment outcome
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 05 Aug 2014 02:19
Last Modified: 05 Aug 2014 02:19

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