Effects of growing-up milk supplemented with prebiotics and LCPUFAs on infections in young children

Chatchatee, P. and Lee, Way Seah and Carrilho, E. and Kosuwon, P. and Simakachorn, N. and Yavuz, Y. and Schouten, B. and Logtens-de Graaff, P. and Szajewska, H. (2014) Effects of growing-up milk supplemented with prebiotics and LCPUFAs on infections in young children. Journal of Pediatric Gastroenterology and Nutrition, 58 (4). pp. 428-437. ISSN 0277-2116, DOI https://doi.org/10.1097/mpg.0000000000000252.

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Official URL: http://journals.lww.com/jpgn/Abstract/2014/04000/E...


Objective: The aim of this study was to investigate the effect of growing-up milk (GUM) with added short-chain galacto-oligosaccharides (scGOS)/long-chain fructo-oligosaccharides (lcFOS) (9:1) (Immunofortis) and n-3 long-chain polyunsaturated fatty acids (LCPUFAs) on the occurrence of infections in healthy children attending day care centres. Methods: In a randomised double-blind controlled, parallel, multicountry intervention study, 767 healthy children, ages 11 to 29 months, received GUM with scGOS/lcFOS/LCPUFAs (the active group, n = 388), GUM without scGOS/lcFOS/LCPUFAs (the control group, n = 379), or cow's milk (n = 37) for 52 weeks. The primary outcome measure was the number of episodes of upper respiratory tract infections or gastrointestinal infections based on a combination of subject's illness symptoms reported by the parents during the intervention period. Results: Children in the active group compared with the control group had a decreased risk of developing at least 1 infection (299/388 77% vs 313/379 83%, respectively, relative risk 0.93, 95% confidence interval CI 0.87-1.00; logistic regression P = 0.03). There was a trend toward a reduction (P = 0.07) in the total number of infections in the active group, which was significant when confirmed by one of the investigators (268/388 69% vs 293/379 77%, respectively, relative risk 0.89, 95% CI 0.82-0.97; P = 0.004, post hoc). More infectious episodes were observed in the cow's milk group, when compared with both GUM groups (34/37 92% vs 612/767 80%, respectively, relative risk 1.15, 95% CI 1.04-1.28). Conclusions: This is the first study in children to show a reduced risk of infection following consumption of GUM supplemented with scGOS/lcFOS/n-3 LCPUFAs. The borderline statistical significance justifies a new study to confirm this finding.

Item Type: Article
Uncontrolled Keywords: Growing-up milk, infection, n-3 LCPUFAs, scGOS/lcFOS, young children
Subjects: R Medicine
R Medicine > RJ Pediatrics > Child health. Child health services
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 14 Jul 2014 00:25
Last Modified: 21 Mar 2019 06:48
URI: http://eprints.um.edu.my/id/eprint/10873

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