Different chemically substituted chitooligosaccharides inhibit beta-secretase activity

Ahmed, A.B.A. and Yoon, N.Y. and Taha, R.M. and Kim, S.K. (2011) Different chemically substituted chitooligosaccharides inhibit beta-secretase activity. Chimica Oggi-Chemistry Today, 29 (5). pp. 77-79. ISSN 0392-839X,


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Chitooligosaccharide or COS is a kind of oligosaccharide that is an integral part of the nervous system. COS is synthesized by chemical substitution and derived AE-COS, DEAE-COS and DMAE-COS that are being shown on IC(50) value. AE-COS and DMAE-COS exhibited four fold less inhibition than DEAE-COS. In addition, non-competitive inhibitor was identified via a Dixon plot and the Ki inhibition constant (100 mu g/mL). We declared, chemical substitution of COS is a water soluble human safe BACE-1 inhibitor.

Item Type: Article
Uncontrolled Keywords: Alzheimers-disease, chitin,
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science
Depositing User: miss munirah saadom
Date Deposited: 06 Aug 2014 00:28
Last Modified: 06 Aug 2014 00:28
URI: http://eprints.um.edu.my/id/eprint/10716

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