Effects of ambient glycaemic state on growth hormone responsiveness in insulin-dependent diabetes

Ismail, I.S. and Scanlon, M.F. and Peters, J.R. (1991) Effects of ambient glycaemic state on growth hormone responsiveness in insulin-dependent diabetes. Clinical Endocrinology, 35. pp. 499-504. ISSN 0300-0664,

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We wished to examine the effects of ambient glycaemia on hypothalamic somatostatinergic tone in insulin-dependent diabetes mellitus. After 6-hour periods of either euglycaemia (5 mmol/l) or hyperglycaemia (15 mmol/l), exercise-induced GH secretion was measured. Seven insulin dependent diabetics with no evidence of complications were recruited. There was no significant difference between basal GH levels during euglycaemia and hyperglycaemia (5.50 vs 5.53 mU/l). Nor was there a significant difference when mean \ GH levels (33.9 vs 27.4 mU/l) or mean area under GH curve (2331 vs 4038 mU min/l) during euglycaemia or hyperglycaemia were compared. We find no evidence therefore to support short-term effects of ambient glucose concentration on GH responsiveness, and by inference no direct effect of shortterm changes in glycaemic control on hypothalamic release of somatostatin in the aetiology of GH hypersecretion in insulin-dependent diabetes mellitus.

Item Type: Article
Additional Information: Department of Medicine, Faculty of Medicine, University of Malaya
Uncontrolled Keywords: Growth hormone; insulin-dependent diabetes
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Ms. Izzan Ramizah Idris
Date Deposited: 10 Nov 2014 01:50
Last Modified: 10 Nov 2014 01:50
URI: http://eprints.um.edu.my/id/eprint/10470

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