Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae)

Awang, Khalijah and Harneti, D. and Supriadin, A. and Ulfah, M. and Safari, A. and Supratman, U. and Hayashi, H. (2014) Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae). Phytochemistry Letters, 8. pp. 28-31. ISSN 1874-3900,

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The new stigmastane steroid,3,4epoxy-(22R,25)-tetrahydrofuran-stigmast-5-en (1), along with two known triterpenoids (2–3) and two known steroids (4–5) were isolated from the stem bark of Aglaia eximia. The chemical structures of the new compound were elucidated on the basis of spectroscopic data. All of the compounds were tested for their cytotoxic effects against P-388 murine leukemia cells.Compounds 1–5 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 11.42, 4.26, 29.10, 45.96, and 52.09 mg/mL, respectively.

Item Type: Article
Additional Information: DOI: 10.1016/j.phytol.2014.01.005
Uncontrolled Keywords: Stigmastane steroid; 3,4-Epoxy-(22R,25)-tetrahydrofuran-stigmast-;5-en; Aglaia eximia; Meliaceae; Cytotoxic activity.
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Suhaila Syakila Alby
Date Deposited: 10 Nov 2014 01:45
Last Modified: 01 Mar 2019 09:23

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