Rhazinilam−leuconolam−leuconoxine alkaloids from leuconotis griffithii

Kam, T.S. and Gan, C.Y. and Low, Y.Y. and Thomas, N.F. (2013) Rhazinilam−leuconolam−leuconoxine alkaloids from leuconotis griffithii. Journal of Natural Products, 76. pp. 957-964. ISSN 0163-3864, DOI https://doi.org/10.1021/np400214y.

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Eight new indole alkaloids (1–8) belonging to the rhazinilam–leuconolam–leuconoxine group, in addition to 52 other alkaloids, were isolated from the stem-bark extract of Leuconotis griffithii, viz., nor-rhazinicine (1), 5,21-dihydrorhazinilam-N-oxide (2), 3,14-dehydroleuconolam (3), and leuconodines A–E (4–8). The structures of these alkaloids were determined using NMR and MS analyses and in some instances confirmed by X-ray diffraction analyses. Alkaloids 1, 5, and 7 showed only moderate to weak cytotoxicity toward KB cells (IC50 12–18 μg/mL), while 8 showed moderate activity in reversing MDR in vincristine-resistant KB cells.

Item Type: Article
Additional Information: Department of Chemistry, University of Malaya
Uncontrolled Keywords: Genus Leuconotis; Lactam carbonyl; Yellowish oil.
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Suhaila Syakila Alby
Date Deposited: 15 Oct 2014 02:19
Last Modified: 15 Oct 2014 02:19
URI: http://eprints.um.edu.my/id/eprint/10373

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