Antibiotics for mastitis in breastfeeding women

Jahanfar, S. and Ng, C.J. and Teng, C.L. (2013) Antibiotics for mastitis in breastfeeding women. Cochrane Database of Systematic Reviews (2). ISSN 1469-493X,

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Background Mastitis can be caused by ineffective positioning of the baby at the breast or restricted feeding. Infective mastitis is commonly caused by Staphylococcus aureus. The prevalence of mastitis in breastfeeding women may reach 33. Effective milk removal, pain medication and antibiotic therapy have been the mainstays of treatment. Objectives This review aims to examine the effectiveness of antibiotic therapies in relieving symptoms for breastfeeding women with mastitis with or without laboratory investigation. Search methods We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 September 2012), contacted investigators and other content experts known to us for unpublished trials and scanned the reference lists of retrieved articles. Selection criteria We selected randomised controlled trials (RCTs) and quasi-RCTs comparing the effectiveness of various types of antibiotic therapies or antibiotic therapy versus alternative therapies for the treatment of mastitis. Data collection and analysis Two review authors independently assessed trial quality and extracted data. When in dispute, we consulted a third author. Main results Two trials met the inclusion criteria. One small trial (n = 25) compared amoxicillin with cephradine and found no significant difference between the two antibiotics in terms of symptom relief and abscess formation. Another, older study compared breast emptying alone as 'supportive therapy' versus antibiotic therapy plus supportive therapy, and no therapy. The findings of the latter study suggested faster clearance of symptoms for women using antibiotics, although the study design was problematic. Authors' conclusions There is insufficient evidence to confirm or refute the effectiveness of antibiotic therapy for the treatment of lactational mastitis. There is an urgent need to conduct high-quality, double-blinded RCTs to determine whether antibiotics should be used in this common postpartum condition.

Item Type: Article
Additional Information: ISI Document Delivery No.: 097GK Times Cited: 0 Cited Reference Count: 44 Jahanfar, Shayesteh Ng, Chirk Jenn Teng, Cheong Lieng University of Malaya, Malaysia; Royal Perak Medical College, Malaysia; International Medical University, Malaysia Internal sourcesUniversity of Malaya, Malaysia.Royal Perak Medical College, Malaysia.International Medical University, Malaysia. Wiley-blackwell Hoboken
Uncontrolled Keywords: Amoxicillin therapeutic use Anti-Bacterial Agents therapeutic use Breast Feeding adverse effects Cephradine therapeutic use Mastitis drug therapy etiology Milk, Human secretion Randomized Controlled Trials as Topic Female Humans lactating women infectious mastitis puerperal mastitis milk inflammation management delivery abscess cohort
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms azrahani halim
Date Deposited: 09 Dec 2014 01:43
Last Modified: 09 Dec 2014 01:43

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