Erectile dysfunction and comorbidities in aging men: An urban cross-sectional study in Malaysia

Khoo, E.M. and Tan, H.M. and Low, W.Y. (2008) Erectile dysfunction and comorbidities in aging men: An urban cross-sectional study in Malaysia. Journal of Sexual Medicine, 5 (12). pp. 2925-2934. ISSN 1743-6095,

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Erectile dysfunction (ED), lower urinary tract symptoms (LUTS), cardiovascular disease (CVD), depression, and androgen deficiency are common conditions affecting aging men over 50 years. However, data were limited in developing countries. To investigate the prevalence of ED, LUTS, chronic diseases, depression, androgen deficiency symptoms, and lifestyle of aging men in Malaysia, and to examine their associations with sociodemographic factors. ED, LUTS, chronic diseases, depression, positive Androgen Deficiency in the Aging Male (ADAM) questionnaire A randomized survey of 351 men using structured questionnaires consisting of self-reported medical conditions, International Index for Erectile Function-5, International Prostate Symptom Score, Geriatric Depression Scale-15, and St Louis University questionnaire for ADAM. Blood samples were taken for glucose, lipid, prostate specific antigen (PSA), and hormones. Mean age was 58 +/- 7 years. Prevalence of ED was 70.1 (mild ED 32.8, mild to moderate ED 17.7, moderate ED 5.1, and severe ED 14.5). There were 29 of men with moderate and severe LUTS; 11.1 had severe depression; 25.4 scored positive on ADAM questionnaire; 30.2 self-reported hypertension, 21.4 self-reported diabetes mellitus; 10.8 self-reported coronary artery disease; 19.1 were smokers; and 34 consumed alcohol. There were 78.6 of men that are overweight and obese; 28.8 had a fasting blood sugar (FBS) >= 6.1 mmol/L, 70.1 had total cholesterol > 5.2 mmol/L, 19.1 had total testosterone >= 11.0 nmoL/L, 14.0 had calculated free testosterone < 0.0225 nmoL/dL; 4 had PSA > 4 mu g/L; 9.4 had insulin-like growth factor-1 (IGF-1) level below age specific range, 5.1 had abnormal sex hormone binding globulin (< 15 nmoL/L and > 70 nmol/L). ED was found to be significantly associated with LUTS, depression (P < 0.001 respectively). Similarly, LUTS was significantly associated with depression and ADAM questionnaire status (P < 0.001 respectively); and ADAM questionnaire status was also significantly associated with depression (P < 0.001). ED, LUTS, depression, and androgen deficiency symptoms are common in urban aging men. As these conditions are possibly interrelated, strategies for early disease prevention and detection are warranted when one disease presents. Khoo EM, Tan HM, and Low WY. Erectile dysfunction and comorbidities in aging men: An urban cross-sectional study in Malaysia. J Sex Med **;**:**-**.

Item Type: Article
Additional Information: Department of Primary Care Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA-----Doi: 10.1111/j.1743-6109.2008.00988.x
Uncontrolled Keywords: Erectile Dysfunction; LUTS; Androgen Deficiency; Depression; Chronic Diseases; Prevalence
Subjects: R Medicine
R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 23 Oct 2014 08:14
Last Modified: 23 Oct 2014 08:14

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