Genetic dynamics and molecular epidemiology of Salmonella typhi

Thong, Kwai Lin and Nair, S. and Subramaniam, G. and Puthucheary, S.D. and Yassin, R.M. and Cheong, Y.M. and Liu, S.L. and Sanderson, K.E. and Cordano, A.M. and Pang, T. (1999) Genetic dynamics and molecular epidemiology of Salmonella typhi. Medical Journal of Indonesia, 7. pp. 147-150.

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Abstract

A large number of S. typhi isolates from various geographic regions, representing sporadic, outbreak, and environmental isolates, as well as isolates from fatal and non-fatal cases of typhoid fever have been analysed by pulsed-field gel electrophoresis (PFGE) with restriction endonucleases XbaI, SpeI, AvrII, and CeuI. The main conclusions are: (1) significant genetic diversities exist among these isolates; (2) outbreak isolates are more homogeneous compared to sporadic isolates; (3) there is movement of certain PFGE types among the countries in South-East Asia; (4) environmental isolates also show diversity and share PFGE types with clinical strains, there appear to be a correlation between PFGE pattern and isolates from fatal disease; (6) limited diversity exists in a region where typhoid fever is a recent introduction; (7) there is significant diversity in total genome size; (8) genomic arrangements within the rrn operon has occurred among many of these strains. Our findings emphasize the genomic plasticity of S. typhi and it is likely that this is closely related to the pathogenic potential and virulence of this organism.

Item Type: Article
Funders: UNSPECIFIED
Additional Information: Institute of Biological Sciences, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Salmonella Typhi
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Prof. Dr Kwai Lin Thong
Date Deposited: 04 Dec 2014 06:42
Last Modified: 12 Oct 2018 06:30
URI: http://eprints.um.edu.my/id/eprint/9974

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