Metabolic syndrome and antipsychotic monotherapy treatment among schizophrenia patients in Malaysia

Said, M.A. and Hatim, A. and Habil, M.H. and Zafidah, W. and Haslina, M.Y. and Badiah, Y. and Ramli, M.A. and Ananjit, S. and Sapini, Y. and Shah, M. and Mahmud, B. and Bulgiba, A. and Hairi, N.N. (2013) Metabolic syndrome and antipsychotic monotherapy treatment among schizophrenia patients in Malaysia. Preventive Medicine. ISSN 0091-7435, DOI https://doi.org/10.1016/j.ypmed.2013.01.005.

PDF Metabolic_syndrome_and_antipsychotic.pdf - Published Version Restricted to Registered users only Download (157kB) | Request a copy

Abstract

Objective: The objective of this study is to determine the prevalence of metabolic syndrome among schizophrenia patients receiving antipsychotic monotherapy in Malaysia. Method: A cross-sectional study was conducted at multiple centres between June 2008 and September 2011. Two hundred and five patients who fulfilled the DSM IV-TR diagnostic criteria for schizophrenia and who had been on antipsychotic medication for at least one year, were screened for metabolic syndrome. Patients receiving a mood stabilizer were excluded from the study. Metabolic syndrome was defined by using the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Treatment Panel III (ATP III) modified for Asian waist circumference. Results: In the first-generation antipsychotic (FGA) group, the highest prevalence of metabolic syndrome was among patients treated with trifluoperazine and flupenthixol decanoate (66.7 each). For the second-generation antipsychotic (SGA) group, the highest prevalence of metabolic syndrome was among patients treated with clozapine (66.7). The component with the highest prevalence in metabolic syndrome was waist circumference in both FGA and SGA groups except for aripiprazole in SGA. Conclusion: The prevalence of metabolic syndrome in schizophrenia patients receiving antipsychotic monotherapy in Malaysia was very high. Intervention measures are urgently needed to combat these problems.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Department of Social and Preventive Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords:	Prevalence; Metabolic syndrome; Schizophrenia; Monotherapy; Antipsychotics
Subjects:	R Medicine
Divisions:	Faculty of Medicine
Depositing User:	Ms Haslinda Lahuddin
Date Deposited:	16 Aug 2013 01:37
Last Modified:	11 Dec 2014 04:36
URI:	http://eprints.um.edu.my/id/eprint/8261

Actions (login required)

View Item