Attenuated levels of pro-inflammatory markers in diabetic retinopathy patients undergoing treatment with antihyperglycemic and antihypertensive drugs

Ng, Z.X. and Chua, K.H. and Tajunisah, I. and Pendek, R. and Kuppusamy, U.R. (2013) Attenuated levels of pro-inflammatory markers in diabetic retinopathy patients undergoing treatment with antihyperglycemic and antihypertensive drugs. Clinics, 68 (2). pp. 185-191. ISSN 1807-5932, DOI https://doi.org/10.6061/clinics/2013(02)OA11.

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Abstract

OBJECTIVE: This study aimed to assess the circulating levels of activated nuclear factor kappa B p65 and monocyte chemotactic protein-1 in diabetic retinopathy patients who were taking antihyperglycemic and antihypertensive drugs. METHODS: In total, 235 healthy controls and 371 Type 2 diabetic patients 171 without retinopathy (DNR) and 200 patients with retinopathy (diabetic retinopathy) were recruited for this study. Plasma and the nuclear fraction of peripheral blood mononuclear cells were isolated for the quantification of the monocyte chemotactic protein-1 and nuclear factor kappa B p65 levels, respectively. RESULTS: Non-medicated diabetic retinopathy patients had significantly higher levels of activated nuclear factor kappa B p65 and plasma monocyte chemotactic protein-1 than DNR patients. Diabetic retinopathy patients who were taking antihyperglycemic and antihypertensive drugs showed significant reductions in both the nuclear factor kappa B p65 and monocyte chemotactic protein-1 levels compared with the non-medicated patients. CONCLUSION: This study demonstrated the significant attenuation of both the nuclear factor kappa B p65 and circulating monocyte chemotactic protein-1 levels in diabetic retinopathy patients taking antihyperglycemic and antihypertensive drugs.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Ng, Zhi Xiang Chua, Kek Heng Tajunisah, Iqbal Pendek, Rokiah Kuppusamy, Umah Rani
Uncontrolled Keywords:	Activated nuclear factor kappa B p65
Subjects:	R Medicine
Divisions:	Faculty of Medicine
Depositing User:	Ms Haslinda Lahuddin
Date Deposited:	23 Jul 2013 00:39
Last Modified:	30 Dec 2014 02:37
URI:	http://eprints.um.edu.my/id/eprint/8169

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