Ariffin, Azhar and Khan, M.N. and Ahmad, W.H.W. (2007) The Kinetic Study On The Effects Of Mixed Aqueous-Organic Solvents On The Rate Of O- And N- Cyclisation Of N-(4 '-Nitrophenyl)Phthalamic Acid. Indian Journal of Chemistry Section a-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry, 46 (3). pp. 416-461. ISSN 0376-4710,
Full text not available from this repository.Abstract
The pseudo-first-order rate constants (k(obs)) for the intramolecular carboxylic group-assisted cleavage of N-(4'-nitrophenyl)phthalamic acid (1) show nonlinear decrease of similar to 17-fold and similar to 117-fold with the increase in the respective contents of CH3CN (10-80% v/v) and 1,4-dioxan (9.5-79.4% v/v) in mixed aqueous solvents. The fraction of N-cyclization of 1 leading to the formation of N-(4'-nitrophenyl)phthalimide, 2, remains almost zero at <= 40% v/v CH3CN while it increases from 0.06 to 0.49 with increase in CH3CN content (50-80% v/v) at 1.0 x 10(-3) M HCl. However, the observed data reveal an almost absence of N-cyclization within 1,4-dioxan content range 10-80% v/v.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA |
| Uncontrolled Keywords: | intramolecular catalysis, amide hydrolysis, phthalanilic acids, phthalic-anhydride, base catalysis, participation, mechanism, cleavage |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Miss Malisa Diana |
| Date Deposited: | 03 Jul 2013 09:02 |
| Last Modified: | 27 Aug 2019 04:53 |
| URI: | http://eprints.um.edu.my/id/eprint/8049 |
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