Ariffin, Azhar and Khan, M.N. and Leng, S.Y. (2004) Effects of tetraalkylammonium salts on alkaline hydrolysis of N-(2-Methoxyphenyl) Phthalimide. Malaysian Journal of Science, 23 (2). pp. 175-180. ISSN 1394-3065,
Full text not available from this repository.Abstract
The effects of the concentrations of Me₄NCI, Pr₄NCl, Bu₄NCl, Me₄NBr, Pr₄NBr and Bu₄NBr on the rate of alkaline hydrolysis of N-(2-methoxyphenyl)phthalimide (N-2MPhPT) at 35°C and in H₂0 solvent containing 2 % (v/v) CH₃CN reveal the formation of ion-pair complexes between solvent - separated loose ion-pair forms ($M^n^+$ ⋯ $X^k^-$) and N-2MPhPT. The bulky hydrophobic tails of tetraalkylammonium salts and their halide anions inhibit the reaction by blocking the OH�?� nucleophilic attack on the reactive site of N-2MPhPT. Among all the quaternary ammonium salts, Me₄NCI showed slight inhibition only because of the shielding effect created by the methyl group is very small. However, Bu₄NBr presents the greatest inhibition on hydrolysis rate because of its strong binding affmity with N-2MPhPT.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA |
| Uncontrolled Keywords: | Tetraalkylammonium Salts, Alkaline Hydrolysis, N-(2-Methoxyphenyl)Phthalimide, Hydrophobic Interactions |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Miss Malisa Diana |
| Date Deposited: | 03 Jul 2013 09:02 |
| Last Modified: | 28 Apr 2021 07:00 |
| URI: | http://eprints.um.edu.my/id/eprint/8043 |
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