Kassim, M. and Yusoff, K.M. and Ong, G. and Sekaran, S. and Yusof, M.Y.B.M. and Mansor, M. (2012) Gelam honey inhibits lipopolysaccharide-induced endotoxemia in rats through the induction of heme oxygenase-1 and the inhibition of cytokines, nitric oxide, and high-mobility group protein B1. Fitoterapia, 83 (6). pp. 1054-1059. ISSN 0367-326X, DOI https://doi.org/10.1016/j.fitote.2012.05.008.
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Abstract
Malaysian Gelam honey has anti-inflammatory and antibacterial properties, a high antioxidant capacity, and free radical-scavenging activity. Lipopolysaccharide (LPS) stimulates immune cells to sequentially release early pro- and anti-inflammatory cytokines and induces the synthesis of several related enzymes. The aim of this study was to investigate the effect of the intravenous injection of honey in rats with LPS-induced endotoxemia. The results showed that after 4 h of treatment, honey reduced cytokine (tumor necrosis factor-α, interleukins 1β, and 10) and NO levels and increased heme oxygenase-1 levels. After 24 h, a decrease in cytokines and NO and an increase in HO-1 were seen in all groups, whereas a reduction in HMGB1 occurred only in the honey-treated groups. These results support the further examination of honey as a natural compound for the treatment of a wide range of inflammatory diseases. © 2012 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Honey; Endotoxemia; Cytokines; High-mobility group box 1; Nitric oxide; Heme oxygenase-1 |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Haslinda Lahuddin |
| Date Deposited: | 08 Jul 2013 06:39 |
| Last Modified: | 08 Jul 2013 06:39 |
| URI: | http://eprints.um.edu.my/id/eprint/7961 |
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