Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease

Tan, Siew Kiat and Pippen, Richard and Yusof, Rohana and Ibrahim, Halijah and Khalid, Norzulaani and Abd Rahman, Noorsaadah (2006) Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease. Bioorganic & Medicinal Chemistry Letters, 16 (12). pp. 3337-3340. ISSN 0960-894X, DOI https://doi.org/10.1016/j.bmcl.2005.12.075.

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Abstract

Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the K-i values of 21 and 25 mu M, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated. (c) 2006 Elsevier Ltd. All rights reserved.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Times Cited: 42 Kiat, TS Pippen, R Yusof, R Ibrahim, H Norzulaani, K Rahman, NA
Uncontrolled Keywords:	Boesenbergia rotunda (L.) extracts; Cyclohexenyl chalcone derivatives; Dengue 2; NS3 protease; Competitive inhibitory activities
Subjects:	Q Science > QD Chemistry Q Science > QH Natural history R Medicine
Divisions:	Faculty of Medicine Faculty of Science > Department of Chemistry Faculty of Science > Institute of Biological Sciences
Depositing User:	Ms Haslinda Lahuddin
Date Deposited:	11 Jul 2013 02:31
Last Modified:	06 Aug 2020 06:19
URI:	http://eprints.um.edu.my/id/eprint/7140

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