MatRahim, Nor-Aziyah and Jones, Kathryn Marie and Keegan, Brian P. and Strych, Ulrich and Zhan, Bin and Lee, Hai-Yen and AbuBakar, Sazaly (2023) TonB-Dependent Receptor Protein Displayed on Spores of Bacillus subtilis Stimulates Protective Immune Responses against Acinetobacter baumannii. Vaccines, 11 (6). ISSN 2076-393X, DOI https://doi.org/10.3390/vaccines11061106.
Full text not available from this repository.Abstract
The emergence of antibiotic-resistant Acinetobacter baumannii strains with limited treatment options has become a significant global health concern. Efforts to develop vaccines against the bacteria have centred on several potential protein targets, including the TonB-dependent receptors (TBDRs). In the present study, TBDRs from A. baumannii were displayed on the surface of Bacillus subtilis spores. The immunogenicity of the recombinant spores was evaluated in orally vaccinated mice. None of the immunized mice demonstrated signs of illness and were observed to be healthy throughout the study. Sera and the intestinal secretions from the recombinant spores-treated mice demonstrated mucosal and humoral antibody responses to the vaccine antigen. In addition, bactericidal activities of the sera against A. baumannii clinical isolates were demonstrated. These observations suggest that the B. subtilis spore-displayed TBDRs should be further explored as much-needed potential oral vaccine candidates against A. baumannii.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya Tropical Infectious Diseases Research and Education Centre (TIDREC) Malaysian-US Neglected Tropical Infectious Diseases Initiative, Ministry of Higher Education, Malaysia under the Higher Institution Centre of Excellence (HICoE) program (MO002-2019) |
| Uncontrolled Keywords: | infectious disease; antibiotic resistance; spores; oral vaccine; immunity |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 29 Jul 2025 04:39 |
| Last Modified: | 29 Jul 2025 04:39 |
| URI: | http://eprints.um.edu.my/id/eprint/50764 |
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