Al-Maweri, Sadeq Ali and Alhajj, Mohammed Nasser and Halboub, Esam and Tamimi, Faleh and Salleh, Nosizana Mohd and Al-Ak'hali, Mohammed Sultan and Kassim, Saba and Abdulrab, Saleem and Anweigi, Lamyia and Mohammed, Marwan Mansoor Ali (2023) The impact of periodontal disease on the clinical outcomes of COVID-19: A systematic review and meta-analysis. BMC Oral Health, 23 (1). ISSN 1472-6831, DOI https://doi.org/10.1186/s12903-023-03378-0.
Full text not available from this repository.Abstract
BackgroundA possible relationship between periodontitis (PD) and COVID-19 and its adverse outcomes has been suggested. Hence, the present systematic review and meta-analysis aimed to investigate the available evidence regarding the potential association between periodontitis (PD) and COVID-19 and its adverse outcomes.Materials and methodsPubMed, Scopus, Web of Science, and Google Scholar were searched for relevant studies published up to April 15th, 2023. Studies that evaluated the association between PD and COVID-19 were included. Risk of bias was evaluated by two reviewers, and meta-analyses were performed using RevMan 5.3 software.ResultsA total of 22 studies involving 92,535 patients from USA, Europe, Asia, the Middle East and South America were included; of these, 12 were pooled into the meta-analysis. Most of the studies (19 studies) reported a significant association between PD and COVID-19. The pooled data found a significant association between PD and COVID-19 outcomes: more severe symptoms (OR = 6.95, P = 0.0008), ICU admissions (OR = 3.15, P = 0.0001), and mortality (OR = 1.92, P = 0.21). Additionally, compared to mild PD, severe PD was significantly associated with higher risks of severe COVID-19 outcomes: severe symptoms (P = 0.02); ICU admission (P = 0.0001); and higher mortality rates (P = 0.0001). The results also revealed 58% higher risk for COVID-19 infection in patients with PD (P = 0.00001).ConclusionsThe present findings suggest a possible association between poor periodontal health and the risk of poor COVID-19 outcomes. However, owing to the observed methodological heterogeneity across the included studies, further prospective cohort studies with standardized methodologies are warranted to further unravel the potential association between periodontal disease and COVID-19 and its adverse outcomes.
| Item Type: | Article |
|---|---|
| Funders: | Open Access funding was provided by Qatar National Library, Qatar National Research Fund (QNRF) |
| Uncontrolled Keywords: | COVID-19 outcomes; Periodontal disease; Association; Systematic review |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry > Department of Restorative Dentistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 08 Sep 2025 01:10 |
| Last Modified: | 08 Sep 2025 01:10 |
| URI: | http://eprints.um.edu.my/id/eprint/50649 |
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