Liew, Adrian and Lydia, Aida and Matawaran, Bien J. and Susantitaphong, Paweena and Tran, Huong Thi Bich and Lim, Lee Ling (2023) Practical considerations for the use of SGLT-2 inhibitors in the Asia-Pacific countries-An expert consensus statement. Nephrology, 28 (8). pp. 415-424. ISSN 1320-5358, DOI https://doi.org/10.1111/nep.14167.
Full text not available from this repository.Abstract
Recent clinical studies have demonstrated the effectiveness of SGLT-2 inhibitors in reducing the risks of cardiovascular and renal events in both patients with and without type 2 diabetes mellitus. Consequently, many international guidelines have begun advocating for the use of SGLT-2 inhibitors for the purpose of organ protection rather than as simply a glucose-lowering agent. However, despite the consistent clinical benefits and available strong guideline recommendations, the utilization of SGLT-2 inhibitors have been unexpectedly low in many countries, a trend which is much more noticeable in low resource settings. Unfamiliarity with the recent focus in their organ protective role and clinical indications; concerns with potential adverse effects of SGLT-2 inhibitors, including acute kidney injury, genitourinary infections, euglycemic ketoacidosis; and their safety profile in elderly populations have been identified as deterring factors to their more widespread use. This review serves as a practical guide to clinicians managing patients who could benefit from SGLT-2 inhibitors treatment and instill greater confidence in the initiation of these drugs, with the aim of optimizing their utilization rates in high-risk populations.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | acute kidney injury; chronic kidney disease; ketosis; sodium-glucose transporter 2 inhibitors; urinary tract infections |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 01 Oct 2025 02:18 |
| Last Modified: | 01 Oct 2025 02:18 |
| URI: | http://eprints.um.edu.my/id/eprint/50318 |
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