Jairoun, A. A. and Ping, C. C. and Ibrahim, B. (2023) Pharmacotherapeutic considerations and treatment patterns of antihyperglycemic agents for diabetic nephropathy: a review of the literature. European Review for Medical and Pharmacological Sciences, 27 (24). pp. 12058-12069. ISSN 1128-3602,
Full text not available from this repository.Abstract
Diabetes can have several mac-rovascular and microvascular complications in addition to diabetic nephropathy, also referred to as diabetic kidney disease (DKD). DKD is found to occur in approximately 40% of patients with type 2 diabetes and 30% of patients with type 1 diabetes. However, research on the ef-fects of antihyperglycemic agents on the renal outcomes of these patients is still in its infancy. The current review explores glycemic manage-ment in patients with DKD, focusing on the chal-lenges faced as well as the clinical consider-ations of antihyperglycemic agents in this pop-ulation. A comprehensive literature review was conducted using EMBASE, Web of Science, and PubMed databases. This review was complet-ed by the end of March 2023, and the following keywords were used for the search: diabetic ne-phropathy, diabetic kidney disease, safety, effi- cacy, and antihyperglycemic therapies. The sev-eral concerns about the use of antihyperglyce-mic agents in treating diabetes in patients with DKD highlight the need for substantial efforts in educating both patients and healthcare practi-tioners in this regard. In addition, it is suggested that patients receive individualized treatments, considering the potential long-term benefits of each agent; this would entail prospectively mod-ifying doses in line with the stage of DKD to pre-vent the progression of renal damage. As some classes of agents offer better renoprotective ef-fects for patients with DKD, it would be wise for nephrologists and endocrinologists to collab-orate to offer an antihyperglycemic regime for patients with DKD who are at a high risk of fur-ther progression. Further study is needed on the beneficial renal effects of specific class- es of agents; more knowledge of their mecha-nisms and renoprotective effects may contrib-ute to the development of novel treatments for patients with DKD.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Diabetic nephropathy; Diabetic kidney disease; Safety; Efficacy; Antihyperglycemic therapies |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 28 Oct 2025 08:33 |
| Last Modified: | 28 Oct 2025 08:33 |
| URI: | http://eprints.um.edu.my/id/eprint/50088 |
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