Hasnan, Muhammad Hafiz Husna and Sivasothy, Yasodha and Khaw, Kooi Yeong and Nafiah, Mohd Azlan and Hazni, Hazrina and Litaudon, Marc and Wan Ruzali, Wan Adriyani and Liew, Sook Yee and Awang, Khalijah (2023) N-Methyl costaricine and costaricine, two potent butyrylcholinesterase inhibitors from Alseodaphne pendulifolia Gamb. International Journal of Molecular Sciences, 24 (13). ISSN 1661-6596, DOI https://doi.org/10.3390/ijms241310699.
Full text not available from this repository.Abstract
Studies have been conducted over the last decade to identify secondary metabolites from plants, in particular those from the class of alkaloids, for the development of new anti-Alzheimer's disease (AD) drugs. The genus Alseodaphne, comprising a wide range of alkaloids, is a promising source for the discovery of new cholinesterase inhibitors, the first-line treatment for AD. With regard to this, a phytochemical investigation of the dichloromethane extract of the bark of A. pendulifolia Gamb. was conducted. Repeated column chromatography and preparative thin-layer chromatography led to the isolation of a new bisbenzylisoquinoline alkaloid, N-methyl costaricine (1), together with costaricine (2), hernagine (3), N-methyl hernagine (4), corydine (5), and oxohernagine (6). Their structures were elucidated by the 1D- and 2D-NMR techniques and LCMS-IT-TOF analysis. Compounds 1 and 2 were more-potent BChE inhibitors than galantamine with IC50 values of 3.51 & PLUSMN; 0.80 & mu;M and 2.90 & PLUSMN; 0.56 & mu;M, respectively. The Lineweaver-Burk plots of compounds 1 and 2 indicated they were mixed-mode inhibitors. Compounds 1 and 2 have the potential to be employed as lead compounds for the development of new drugs or medicinal supplements to treat AD.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya Research Grant [Grant No: GPF039A-2020 ; GPF039B-2020 ; RK011-2020] |
| Uncontrolled Keywords: | Alseodaphne pendulifolia Gamb; Lauraceae; Alkaloid; bisbenzylisoquinoline; Aporphine; Oxoaporphine; Acetylcholinesterase; Butyrylcholinesterase |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 08 Nov 2025 11:09 |
| Last Modified: | 08 Nov 2025 11:09 |
| URI: | http://eprints.um.edu.my/id/eprint/49737 |
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