Rahman, Mahfoozur and Afzal, Obaid and Ullah, Shehla Nasar Mir Najib and Alshahrani, Mohammad Y. and Alkhathami, Ali G. and Altamimi, Abdulmalik Saleh Alfawaz and Almujri, Salem Salman and Almalki, Waleed H. and Shorog, Eman M. and Alossaimi, Manal A. and Mandal, Ashok Kumar and Abdulrahman, Alhamyani and Sahoo, Ankit (2023) Nanomedicine-based drug-targeting in breast cancer: pharmacokinetics, clinical progress, and challenges. ACS Omega, 8 (51). pp. 48625-48649. ISSN 2470-1343, DOI https://doi.org/10.1021/acsomega.3c07345.
Full text not available from this repository.Abstract
Breast cancer (BC) is a malignant neoplasm that begins in the breast tissue. After skin cancer, BC is the second most common type of cancer in women. At the end of 2040, the number of newly diagnosed BC cases is projected to increase by over 40%, reaching approximately 3 million worldwide annually. The hormonal and chemotherapeutic approaches based on conventional formulations have inappropriate therapeutic effects and suboptimal pharmacokinetic responses with nonspecific targeting actions. To overcome such issues, the use of nanomedicines, including liposomes, nanoparticles, micelles, hybrid nanoparticles, etc., has gained wider attention in the treatment of BC. Smaller dimensional nanomedicine (especially 50-200 nm) exhibited improved in vivo effectiveness, such as better tissue penetration and more effective tumor suppression through enhanced retention and permeation, as well as active targeting of the drug. Additionally, nanotechnology, which further extended and developed theranostic nanomedicine by incorporating diagnostic and imaging agents in one platform, has been applied to BC. Furthermore, hybrid and theranostic nanomedicine has also been explored for gene delivery as anticancer therapeutics in BC. Moreover, the nanocarriers' size, shape, surface charge, chemical compositions, and surface area play an important role in the nanocarriers' stability, cellular absorption, cytotoxicity, cellular uptake, and toxicity. Additionally, nanomedicine clinical translation for managing BC remains a slow process. However, a few cases are being used clinically, and their progress with the current challenges is addressed in this Review. Therefore, this Review extensively discusses recent advancements in nanomedicine and its clinical challenges in BC.
| Item Type: | Article |
|---|---|
| Funders: | Deanship of Scientific Research ??? King Khalid University, Asir-Abha 61421, Saudi Arabia [Grant No: RGP1/245/44], King Khalid University, King Saud University |
| Uncontrolled Keywords: | Walled carbon nanotubes; Solid lipid nanoparticles; Therapy |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 10 Nov 2025 04:57 |
| Last Modified: | 10 Nov 2025 04:57 |
| URI: | http://eprints.um.edu.my/id/eprint/49575 |
Actions (login required)
 |
View Item |
