Fauzi, Muhammad Al Rizqi Dharma and Pudjiastuti, Pratiwi and Hendradi, Esti and Widodo, Riyanto Teguh (2023) Development of a potential carrageenan-based hard capsule as the alternative of conventional capsules by implementing the oligomerization reaction. Journal of Saudi Chemical Society, 27 (4). ISSN 1319-6103, DOI https://doi.org/10.1016/j.jscs.2023.101672.
Full text not available from this repository.Abstract
Carrageenan-based (CRG) hard capsules have a slower disintegration rate compared to that of gelatin capsules. Therefore, there is an urgent need to optimize the performance of this mate-rial using the oligomerization process. The preparation was conducted by oligomerizing CRG, cross-linking it with maltodextrin (MD), and plasticizing it with sorbitol (SOR). Based on our research, we found that the capsule prepared with the code CRG(O)-MD/SOR had an ash content of 11.80% and a water content of 17.20 & PLUSMN; 1.20 %. No microbes or yeast were found in the capsule, and only negligible amounts of heavy metal traces were present. Scanning electron microscopy (SEM) morphology analysis of the capsule surface showed that no pores were observed, even at a magnification of 10,000 times. This result was supported by the BET-BJH analysis, which showed that the pores had an average diameter of 49.26 A. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) showed that the Tg of the prepared capsules was at 51.4 & DEG;C. Fourier-transform infrared spectroscopy (FTIR) analysis showed that the presence of citric acid as the oligomerization agent had changed the chain composition of the carrageenan. Acute toxicity analysis showed that the capsule was safe even at a dose of 3,000 mg/bw. The Young's modulus of CRG(O)-MD/SOR was determined to be 1.500 & PLUSMN; 0.52 MPa. In vitro disintegration testing of CRG
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Culture, Research and Technology of Republic of Indonesia |
| Uncontrolled Keywords: | Drug delivery system; Carrageenan; Hard capsule; Oligomerization; Good health and well-being |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Pharmacy |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 30 Oct 2025 07:53 |
| Last Modified: | 30 Oct 2025 07:53 |
| URI: | http://eprints.um.edu.my/id/eprint/48715 |
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