Mueller-Nedebock, Amica C. and Dekker, Marieke C. J. and Farrer, Matthew J. and Hattori, Nobutaka and Lim, Shen-Yang and Mellick, George D. and Rektorova, Irena and Salama, Mohamed and Schuh, Artur F. S. and Stoessl, A. Jon and Sue, Carolyn M. and Tan, Ai Huey and Vidal, Rene L. and Klein, Christine and Bardien, Soraya (2023) Different pieces of the same puzzle: A multifaceted perspective on the complex biological basis of Parkinson's disease. NPJ Parkinson's Disease, 9 (1). ISSN 2373-8057, DOI https://doi.org/10.1038/s41531-023-00535-8.
Full text not available from this repository.Abstract
The biological basis of the neurodegenerative movement disorder, Parkinson's disease (PD), is still unclear despite it being `discovered' over 200 years ago in Western Medicine. Based on current PD knowledge, there are widely varying theories as to its pathobiology. The aim of this article was to explore some of these different theories by summarizing the viewpoints of laboratory and clinician scientists in the PD field, on the biological basis of the disease. To achieve this aim, we posed this question to thirteen ``PD experts'' from six continents (for global representation) and collated their personal opinions into this article. The views were varied, ranging from toxin exposure as a PD trigger, to LRRK2 as a potential root cause, to toxic alpha-synuclein being the most important etiological contributor. Notably, there was also growing recognition that the definition of PD as a single disease should be reconsidered, perhaps each with its own unique pathobiology and treatment regimen.
| Item Type: | Article |
|---|---|
| Funders: | American University in Cairo, European Commission, Shake it Up Australia, Ministerstvo Školství, Mládeže a Tělovýchovy, University of Malaya Parkinson’s Disease and Movement Disorders Research Program [Grant no. PV035–2017], Ministerstvo Zdravotnictví Ceské Republiky [Grant no. NU20–04–00294, LX22NPO5107], National Health and Medical Research Council [Grant no. 1136800, APP1136800] |
| Uncontrolled Keywords: | Alpha synuclein; Toxin |
| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 30 Oct 2025 04:35 |
| Last Modified: | 30 Oct 2025 04:35 |
| URI: | http://eprints.um.edu.my/id/eprint/48697 |
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