Thye, Chee Keong and Lee, Yee Wan and Jalalonmuhali, Maisarah and Lim, Soo Kun and Ng, Kok Peng (2023) Creatinine clearance in selection of living kidney donor among the Malaysian population: is it safe? BMC NEPHROLOGY, 24 (1). ISSN 1471-2369, DOI https://doi.org/10.1186/s12882-023-03057-w.
Full text not available from this repository.Abstract
BackgroundAssessment of donor renal function is made by the measurement of Glomerular Filtration Rate (GFR). Exogenous markers are preferred over creatinine clearance and are widely used for measuring GFR. However, they are difficult to obtain, costly and laborious. This is a study to look into the safety and accuracy of creatinine clearance for renal assessment among the living kidney donors in the Malaysian population.MethodsThis is a retrospective, single-centre study comprising 105 living kidney donor candidates from the year 2007 to 2020. By comparing against 51-Chromium ethylenediamine-tetraacetic acid (51Cr-EDTA), we analysed creatinine clearance for correlation, bias, precision and accuracy.ResultsThe study group had a mean age of 45.68 & PLUSMN; 10.97 years with a mean serum creatinine of 64.43 & PLUSMN; 17.68 & mu;mol/L and a urine volume of 2.06 & PLUSMN; 0.83 L. Mean measured GFR from 51Cr-EDTA was 124.37 & PLUSMN; 26.83 ml/min/1.73m2 whereas mean creatinine clearance was 132.35 & PLUSMN; 38.18 ml/min/1.73m2. Creatinine clearance overestimated 51Cr-EDTA significantly with a correlation coefficient of 0.48 (p < 0.001) and an accuracy of 78.10% and 64.0% within 30% and 20% respectively of 51Cr-EDTA.ConclusionCreatinine clearance is an acceptable and affordable alternative for donor renal assessment in the absence of exogenous markers with an emphasis on adequate urine collection followed by using measured GFR in selected cases.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Kidney transplant; Donor renal assessment; Creatinine clearance; Chromium 51 ethylenediamine-tetraacetic acid |
| Subjects: | R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 01 Nov 2025 13:41 |
| Last Modified: | 01 Nov 2025 13:41 |
| URI: | http://eprints.um.edu.my/id/eprint/48636 |
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