Ramachandran, Chitra Devi and Gholami, Khadijeh and Lam, Sau-Kuen and Hoe, See-Ziau (2023) Effects of a high-salt diet on MAP and expression levels of renal ENaCs and aquaporins in SHR. Experimental Biology and Medicine, 248 (20). pp. 1768-1779. ISSN 1535-3702, DOI https://doi.org/10.1177/15353702231198085.
Full text not available from this repository.Abstract
An increase in blood pressure by a high-salt (HS) diet may change the expression levels of renal epithelial sodium channels (ENaCs) and aquaporins (AQPs). Spontaneously hypertensive rats (SHRs) and Wistar Kyoto (WKY) rats were exposed to HS and regular-salt (RS) diets for 6 weeks. Mean arterial pressure (MAP) and plasma atrial natriuretic peptide (ANP), angiotensin II (Ang II), aldosterone, and arginine vasopressin (AVP) levels were determined. Expression of mRNA levels of ENaCs and AQPs were quantified by real-time PCR. The MAP was higher in SHRs on the HS diet. Plasma Ang II and aldosterone levels were low while plasma ANP level was high in both strains of rats. Renal expression of mRNA levels of alpha-, beta-, and gamma-ENaCs was lowered in SHRs on the HS diet. Meanwhile, renal AQP1, AQP2, and AQP7 mRNA expression levels were lowered in both strains of rats on the HS diet. Suppression of mRNA expression levels of ENaC and AQP subunits suggests that the high-salt-induced increase in the MAP of SHR may not be solely due to renal sodium and water retention.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya [Grant No: PG274-2016A] |
| Uncontrolled Keywords: | High-salt diet; Mean arterial pressure (MAP); Epithelial sodium channels (ENaCs); Aquaporins (AQPs); Kidneys |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Nov 2025 01:55 |
| Last Modified: | 03 Nov 2025 01:55 |
| URI: | http://eprints.um.edu.my/id/eprint/48608 |
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