Kumar, Mohit and Hilles, Ayah. R. and Ge, Yi and Bhatia, Amit and Mahmood, Syed (2023) A review on polysaccharides mediated electrospun nanofibers for diabetic wound healing: Their current status with regulatory perspective. International Journal of Biological Macromolecules, 234. ISSN 0141-8130, DOI https://doi.org/10.1016/j.ijbiomac.2023.123696.
Full text not available from this repository.Abstract
The current treatment strategies for diabetic wound care provide only moderate degree of effectiveness; hence new and improved therapeutic techniques are in great demand. Diabetic wound healing is a complex physio-logical process that involves synchronisation of various biological events such as haemostasis, inflammation, and remodelling. Nanomaterials like polymeric nanofibers (NFs) offer a promising approach for the treatment of diabetic wounds and have emerged as viable options for wound management. Electrospinning is a powerful and cost-effective method to fabricate versatile NFs with a wide array of raw materials for different biological ap-plications. The electrospun NFs have unique advantages in the development of wound dressings due to their high specific surface area and porosity. The electrospun NFs possess a unique porous structure and biological function similar to the natural extracellular matrix (ECM), and are known to accelerate wound healing. Compared to traditional dressings, the electrospun NFs are more effective in healing wounds owing to their distinct charac-teristics, good surface functionalisation, better biocompatibility and biodegradability. This review provides a comprehensive overview of the electrospinning procedure and its operating principle, with special emphasis on the role of electrospun NFs in the treatment of diabetic wounds. This review discusses the present techniques applied in the fabrication of NF dressings, and highlights the future prospects of electrospun NFs in medicinal applications.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Electrospinning; Diabetic wound healing; Nanofibers; Natural polysaccharides; Scaffold |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmaceutical Technology |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 23 Oct 2025 21:25 |
| Last Modified: | 23 Oct 2025 21:25 |
| URI: | http://eprints.um.edu.my/id/eprint/48391 |
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