A low-cost, portable, and mobile-based bioimpedance lymphedema diagnosis and monitoring system (Mobilymph): A validation Study

Syed Ibrahim, Syarifah Aisyah and Ibrahim, Fatimah and Mohd Taib, Nur Aishah and Cho, Jongman (2023) A low-cost, portable, and mobile-based bioimpedance lymphedema diagnosis and monitoring system (Mobilymph): A validation Study. Lymphatic Research and Biology, 21 (5). pp. 463-468. ISSN 1539-6851, DOI https://doi.org/10.1089/lrb.2022.0102.

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Abstract

Background: Breast cancer-related lymphedema (BCRL) is a debilitating chronic illness. Early management and prevention of disease progression rely on lymphedema monitoring and assessment. At present, lymphedema monitoring systems are costly and do not promote remote monitoring. Thus, a low-cost, portable, mobile-based bioimpedance lymphedema monitoring system (Mobilymph) was developed to ensure continuous lymphedema surveillance.Method and Results: Forty-five healthy and 100 BCRL participants were recruited in this study. Mobilymph bioimpedance measurement was validated with a Quadscan 4000 on healthy participants' arms. The interarm bioimpedance ratio was determined to evaluate the discriminatory capability of Mobilymph to detect BCRL. Mobilymph's bioimpedance results show no significant difference compared to Quadscan 4000. The interarm bioimpedance ratios were significantly different (p < 0.001), between participants in healthy and Stage 1, Stage 0 and Stage 1, and Stage 1 and Stage 2. Healthy and Stage 0 participants had similar interarm impedance ratios (p = 0.63).Conclusion: The bioimpedance results show that Mobilymph bioimpedance measurement is comparable to Quadscan 4000 and can detect BCRL arms. Thus, Mobilymph lymphedema monitoring system offers a feasible solution for early lymphedema diagnosis and treatment monitoring.Clinical trial registration number: MREC ID No.: 2020316-8181

Item Type: Article
Funders: Geran University of Malaya [Grant no. RU005A-2016, RU007C-2017K]
Uncontrolled Keywords: Breast cancer-related lymphedema; Bioimpedance; Low-cost; Portable; Monitoring; Detection
Subjects: R Medicine > R Medicine (General) > Medical technology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Engineering > Department of Biomedical Engineering
Faculty of Medicine > Surgery Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 26 Oct 2025 04:56
Last Modified: 26 Oct 2025 04:56
URI: http://eprints.um.edu.my/id/eprint/48311

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