Yusof, Ruhana Che and Norhayati, Mohd Noor and Azman, Yacob Mohd (2023) Bacterial coinfection and antibiotic resistance in hospitalized COVID-19 patients: A systematic review and meta-analysis. PeerJ, 11. ISSN 2167-8359, DOI https://doi.org/10.7717/peerj.15265.
Full text not available from this repository.Abstract
Background: There were a few studies on bacterial coinfection in hospitalized COVID-19 patients worldwide. This systematic review aimed to provide the pooled prevalence of bacterial coinfection from published studies from 2020 to 2022. Methods: Three databases were used to search the studies, and 49 studies from 2,451 identified studies involving 212,605 COVID-19 patients were included in this review. Results: The random-effects inverse-variance model determined that the pooled prevalence of bacterial coinfection in hospitalized COVID-19 patients was 26.84% (95% CI 23.85-29.83]). The pooled prevalence of isolated bacteria for Acinetobacter baumannii was 23.25% (95% CI 19.27-27.24]), Escherichia coli was 10.51% (95% CI 8.90-12.12]), Klebsiella pneumoniae was 15.24% (95% CI 7.84-22.64]), Pseudomonas aeruginosa was 11.09% (95% CI 8.92-13.27]) and Staphylococcus aureus (11.59% (95% CI 9.71-13.46])). Meanwhile, the pooled prevalence of antibiotic-resistant bacteria for extended-spectrum beta-lactamases producing Enterobacteriaceae was 15.24% (95% CI 7.84-22.64]) followed by carbapenem-resistant Acinetobacter baumannii (14.55% (95% CI 9.59-19.52%])), carbapenem-resistant Pseudomonas aeruginosa (6.95% (95% CI 2.61-11.29])), methicillin-resistant Staphylococcus aureus (5.05% (95% CI 3.49-6.60])), carbapenem-resistant Enterobacteriaceae (4.95% (95% CI 3.10-6.79])), and vancomycin-resistant Enterococcus (1.26% (95% CI 0.46-2.05])). Conclusion: All the prevalences were considered as low. However, effective management and prevention of the infection should be considered since these coinfections have a bad impact on the morbidity and mortality of patients.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Bacterial coinfection; COVID-19; Antibiotic-resistant bacteria; Prevalence; Systematic review |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 24 Oct 2025 08:22 |
| Last Modified: | 24 Oct 2025 08:22 |
| URI: | http://eprints.um.edu.my/id/eprint/48309 |
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