Faizal, Aizatul Shafiqah Mohd and Hon, Wei Yin and Thevarajah, T. Malathi and Khor, Sook Mei and Chang, Siow-Wee (2023) A biomarker discovery of acute myocardial infarction using feature selection and machine learning. Medical & Biological Engineering & Computing, 61 (10). pp. 2527-2541. ISSN 0140-0118, DOI https://doi.org/10.1007/s11517-023-02841-y.
Full text not available from this repository.Abstract
Acute myocardial infarction (AMI) or heart attack is a significant global health threat and one of the leading causes of death. The evolution of machine learning has greatly revamped the risk stratification and death prediction of AMI. In this study, an integrated feature selection and machine learning approach was used to identify potential biomarkers for early detection and treatment of AMI. First, feature selection was conducted and evaluated before all classification tasks with machine learning. Full classification models (using all 62 features) and reduced classification models (using various feature selection methods ranging from 5 to 30 features) were built and evaluated using six machine learning classification algorithms. The results showed that the reduced models performed generally better (mean AUPRC via random forest (RF) algorithm for recursive feature elimination (RFE) method ranges from 0.8048 to 0.8260, while for random forest importance (RFI) method, it ranges from 0.8301 to 0.8505) than the full models (mean AUPRC via RF: 0.8044). The most notable finding of this study was the identification of a five-feature model that included cardiac troponin I, HDL cholesterol, HbA1c, anion gap, and albumin, which had achieved comparable results (mean AUPRC via RF: 0.8462) as to the models that containing more features. These five features were proven by the previous studies as significant risk factors for AMI or cardiovascular disease and could be used as potential biomarkers to predict the prognosis of AMI patients. From the medical point of view, fewer features for diagnosis or prognosis could reduce the cost and time of a patient as lesser clinical and pathological tests are needed.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Impact Oriented Interdisciplinary Research Grant [Grant No: IIRG020B-2019; IIRG020C-2019] |
| Uncontrolled Keywords: | Acute myocardial infarction; Heart attack; Machine learning; Feature selection; Biomarker; Classification |
| Subjects: | Q Science > QA Mathematics > QA75 Electronic computers. Computer science Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine Faculty of Science |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 06 Oct 2025 13:24 |
| Last Modified: | 06 Oct 2025 13:24 |
| URI: | http://eprints.um.edu.my/id/eprint/48279 |
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