Leu, K. F. and Menaga, Subramaniam and Wang, Xinghua and Yang, Z. and Yap, Lee Fah and Lo, K. Wai and Lim, Yang Mooi (2023) A global gene expression study on Xiao Xian Xiong decoction-treated hone-1. Indian Journal of Pharmaceutical Sciences, 85 (5). pp. 1485-1503. ISSN 0250-474X,
Full text not available from this repository.Abstract
Leu et al.: Study on Xiao Xian Xiong Decoction-Treated Hone-1In Malaysia, nasopharyngeal carcinoma is the 5th (4.0 %) most prevalent malignant tumor and it is the 3rd highest in male for cancer occurrence rate (8.4 %). Therefore, discovery of novel anti-cancer herbal drugs is of importance. In this study, the cytotoxic effect of traditional Chinese herbal prescription Xiao Xian Xiong decoction which made up of Huanglian (Coptis chinensis Franch.), Banxia (Pinellia ternata (Thunb.) Breit.), and Gualou (Trichosanthes kirilowaii Maxim) was tested. The cytotoxic effect Xiao Xian Xiong decoction was studied on 8 nasopharyngeal cancer cell lines (TWO-1, TWO-4, HONE-1, SUNE-1, CNE-2, HK-1, CNE-1 and C666-10). Global gene expression analysis was conducted using nCounter XT gene expression assay. The half-maximal inhibitory concentration values obtained for Xiao Xian Xiong decoction-treated HONE-1 and CNE-2 cell lines were 88.55 and 92.42 mu g/ml respectively. Global gene expression showed Xiao Xian Xiong decoction significantly downregulated genes that are associated with cell growth and proliferation, whereas upregulated genes that are associated with induced cell cycle arrest and apoptosis in HONE-1 cells.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Tunku Abdul Rahman Research Fund (UTARRF) [Grant no. IPSR/RMC/UTARRF/201 7-C 1-W01] |
| Uncontrolled Keywords: | Huanglian; malignant; Nasopharyngeal carcinoma; Xiao Xian Xiong decoction |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry > Department of Oral & Craniofacial Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Oct 2025 14:26 |
| Last Modified: | 20 Oct 2025 14:26 |
| URI: | http://eprints.um.edu.my/id/eprint/48154 |
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