Khan, Zia ur Rehman and Assad, Nasir and Naeem-ul-Hassan, Muhammad and Sher, Muhammad and Alatawi, Suliman and Alatawi, Mohsen Suliman and Omran, Awatif M. E. and Jame, Rasha M. A. and Adnan, Muhammad and Khan, Muhammad Nauman and Ali, Baber and Wahab, Sana and Razak, Sarah Abdul and Javed, Muhammad Ammar and Kaplan, Alevcan and Rahimi, Mehdi (2023) Aconitum lycoctonum L. (Ranunculaceae) mediated biogenic synthesis of silver nanoparticles as potential antioxidant, anti-inflammatory, antimicrobial and antidiabetic agents. BMC Chemistry, 17 (1). ISSN 2661-801X, DOI https://doi.org/10.1186/s13065-023-01047-5.
Full text not available from this repository.Abstract
In this study, a polar extract of Aconitum lycoctonum L. was used for the synthesis of silver nanoparticles (AgNPs), followed by their characterization using different techniques and evaluation of their potential as antioxidants, amylase inhibitors, anti-inflammatory and antibacterial agents. The formation of AgNPs was detected by a color change, from transparent to dark brown, within 15 min and a surface resonance peak at 460 nm in the UV-visible spectrum. The FTIR spectra confirmed the involvement of various biomolecules in the synthesis of AgNPs. The average diameter of these spherical AgNPs was 67 nm, as shown by the scanning electron micrograph. The inhibition zones showed that the synthesized nanoparticles inhibited the growth of Gram-positive and negative bacteria. FRAP and DPPH assays were used to demonstrate the antioxidant potential of AgNPs. The highest value of FRAP (50.47% AAE/mL) was detected at a concentration of 90 ppm and a DPPH scavenging activity of 69.63% GAE was detected at a concentration of 20 mu g/mL of the synthesized AgNPs. 500 mu g/mL of the synthesized AgNPs were quite efficient in causing 91.78% denaturation of ovalbumin. The AgNPs mediated by A. lycoctonum also showed an inhibitory effect on alpha-amylase. Therefore, AgNPs synthesized from A. lycoctonum may serve as potential candidates for antibacterial, antioxidant, anti-inflammatory, and antidiabetic agents.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | A. lycoctonum; Antibacterial; Antidiabetic; Anti-inflammatory; Antioxidant; Silver nanoparticles |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 12 Oct 2025 00:05 |
| Last Modified: | 12 Oct 2025 00:05 |
| URI: | http://eprints.um.edu.my/id/eprint/48130 |
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