Fostering healthy cognitive ageing in people living with HIV

Cysique, Lucette A. and Levin, Jules and Howard, Chris and Taylor, Jeff and Rule, John and Costello, Jane and Bruning, Jane and Njeri, Priscilla and Mullens, Amy B. and Wright, Edwina and Gouse, Hetta and Daken, Kirstie and Aung, Htein Linn and Robbins, Reuben N. and Ferraris, Christopher M. and Munoz-Moreno, Jose A. and Woods, Steven P. and Moore, David J. and Power, Christopher and Wong, Pui Li and Hasmukharay, Kejal and Nyamayaro, Primrose and Vera, Jaime and Rajasuriar, Reena and Heaton, Robert K. and Goodkin, Karl and Letendre, Scott and Ellis, Ronald J. and Brew, Bruce J. and Rourke, Sean B. and Grp, NeuroHIV & Aging Advocacy (2025) Fostering healthy cognitive ageing in people living with HIV. Lancet HIV, 12 (1). e71-e80. ISSN 2352-3018, DOI https://doi.org/10.1016/S2352-3018(24)00248-0.

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Abstract

Prevalence and incidence of HIV among people aged 50 years and older continue to rise worldwide, generating increasing awareness among care providers, scientists, and the HIV community about the importance of brain health in older adults with HIV. Many age-related factors that adversely affect brain health can occur earlier and more often among people with HIV, including epigenetic ageing, chronic medical conditions (eg, cardiovascular disease), and age-related syndromes (eg, frailty). Extensive dialogue between HIV community leaders, health-care providers, and scientists has led to the development of a multidimensional response strategy to protect and enhance brain health people ageing with HIV that spans across public health, clinical spaces, and research spaces. This response strategy was informed by integrated ageing care frameworks and is centred on prevention, early detection, and management of brain health issues associated with HIV (eg, neurocognitive disorders), with specific considerations for low resource or middle-resource countries. A collaborative, international, and data-informed update of the diagnostic criteria for HIV-associated neurocognitive disorders is a cornerstone of the proposed response strategy. The proposed response strategy includes a dynamic, international, online knowledge hub that will provide a crucial community resource for emerging evidence on the brain health of people ageing with HIV.

Item Type: Article
Funders: MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St Michael's Hospital, Ontario, Canada, Michael Musgrave Fellowship in NeuroHIV at St Vincent's Curran Foundation, Sydney, Australia
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Medicine Department
Centre of Excellence for Research in AIDS (CERiA)
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 14 May 2025 08:24
Last Modified: 14 May 2025 08:24
URI: http://eprints.um.edu.my/id/eprint/48016

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