Thavaraj, Selvam and Henley-Smith, Rhonda and Gregson-Williams, Harry and Yogarajah, Sangeetha and Odell, Edward W. and Sathasivam, Hans (2025) Clinico-pathological characterisation of human papillomavirus-associated oral epithelial dysplasia. Oral Oncology, 162. ISSN 1368-8375, DOI https://doi.org/10.1016/j.oraloncology.2025.107182.
Full text not available from this repository.Abstract
Background: Human papillomavirus-associated oral epithelial dysplasia (HPV-OED) has been recently recognised by the World Health Organisation (WHO) as a distinct type of oral epithelial dysplasia. The rarity of HPV-OED, together with gaps in the current understanding of risk factors and clinical behaviour raise the risk of under- recognition and misdiagnosis. To address this, we describe the clinico-pathological features of a consecutive series of HPV-OED from a single institution to provide additional insight into the presentation and behaviour of this disease. Methods: Consecutive cases of HPV-OED were identified over a 20-year period from the pathology routine diagnostic archives of a single centre. Cases with features of viral cytopathic changes in a background of OED underwent HPV-specific testing in addition to p16 immunohistochemistry to confirm HPV positivity. Results: Fifty-three consecutive patients with HPV-OED were identified. The mean age at diagnosis was 55 years- old and there was a strong male predilection (83 %). Most patients were smokers or former smokers, and almost a fifth of individuals were Human Immunodeficiency Virus (HIV)-positive. The latero-ventral tongue was the most common index site. Twenty-eight percent of cases were associated with invasive oral squamous cell carcinoma. There was a statistically significant association between with patient's HIV status and malignant transformation (p = 0.022). Conclusions: Findings from our cohort of HPV-OED patients suggests that malignant transformation is relatively frequent and associated with the HIV status of patients.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Human papillomavirus; Oral cavity; Dysplasia |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry > Department of Oral & Maxillofacial Clinical Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 01 Oct 2025 08:37 |
| Last Modified: | 01 Oct 2025 08:37 |
| URI: | http://eprints.um.edu.my/id/eprint/47975 |
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